![]() We further offer the hypothesis that MHAP may arise from the neoplastic transformation of a more differentiated cell in the crypt than the traditional adenoma. We conclude that these lesions reflect a morphologically unique variant of adenoma and suggest that they be termed "serrated adenoma" in order to emphasize their neoplastic nature. Thirty-seven percent of MHAP contained foci of significant dysplasia 11% contained areas of intramucosal carcinoma. Hyperplastic polyps Hyperplastic polyps are usually small, located in the end-portion of the colon (the rectum and sigmoid colon. Other types of polyps can also be found in the colon, although these are far less common and are not discussed here. Although surface mitotic activity, nuclear pseudostratification, and nuclear cytoplasmic ratio were greater in MHAP than in hyperplastic polyps, they were slightly less than in traditional adenomas. The most common types of polyps are hyperplastic and adenomatous polyps. However, MHAP were distinguished by the presence of goblet cell immaturity, upper zone mitoses, prominence of nucleoli, and the absence of a thickened collagen table. All MHAP were characterized by a serrated glandular pattern simulating that seen in hyperplasia (27% of MHAP were initially diagnosed as hyperplastic polyps). They were distributed throughout the colorectum, but a slight preponderance of large lesions (more than 1.0 cm) occurred in the cecum and appendix. Five patients had two or more (up to seven) lesions. Tubulovillous adenoma polyps are not cancer, but they are pre-cancerous (meaning that they can turn into cancers). The patients with MHAP ranged in age from 15 to 88 years (mean, 63 years). Tubulovillous adenoma is a type of polyp that grows in the colon and other places in the gastrointestinal tract and sometimes in other parts of the body. They are compared with 60 traditional adenomas, 40 hyperplastic polyps, and five colonic polyps that contained admixed but well-defined hyperplastic and adenomatous glands (HP/AD). However, if larger polyps or cancerous polyps are found, you may need several follow-up colonoscopies in the span of a few years.We present the clinicopathologic characteristics of 110 colorectal mixed hyperplastic adenomatous polyps (MHAP) that exhibited the architectural but not the cytologic features of a hyperplastic polyp. If small polyps are found, your doctor may suggest a return visit in as little as five years. If your doctor doesn’t find any adenomas or polyps, the next screening may not be necessary for 10 years. Ask when you should be screened again.You can also reduce your risk for polyps and cancer by losing weight and exercising. While it’s unclear why colon polyps develop, doctors do know you can lower your risk by eating a healthy diet with fiber and reduced fat. If the polyp is precancerous or cancerous, your doctor may want to remove it quickly. This may include a watchful waiting period where you don’t take action. If polyps were found and tested, what needs to happen to them? Talk with your doctor about a treatment plan. They’ll likely have images of any polyps, and they’ll also have results of biopsies back within a few days. In your follow-up appointment, ask your doctor about the results of the colonoscopy. Your doctor can talk about your individual risk and things you can do to lower your risk in the future. Lifestyle and genetic factors may influence your risk for developing colon cancer or precancer. Ask if you’re at an increased risk of colon cancer.Use these talking points to start the conversation: If you’re preparing for a colonoscopy or colon cancer screening, talk with your doctor about your risk for colon cancer and what will be done if polyps are found.
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